Drug interactions
Belumosudil + Efavirenz
Severity: Moderate
Belumosudil and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and can lower belumosudil concentrations, risking reduced efficacy in chronic graft-versus-host disease. The legacy direction of effect is wrong.
What this interaction means in plain words
Belumosudil and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belumosudil belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
CYP3A4 induction accelerates belumosudil metabolism.
What to do
Increase belumosudil to 200 mg twice daily during co-therapy, as per labeling. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Belumosudil
- Amobarbital + Belumosudil Moderate
- Apalutamide + Belumosudil Moderate
- Armodafinil + Belumosudil Moderate
- Belumosudil + Bosentan Moderate
- Belumosudil + Carbamazepine Moderate
- Belumosudil + Dexlansoprazole Moderate
Frequently asked questions
Can I take Belumosudil with Efavirenz?
MediHelp rates the interaction as moderate. Belumosudil and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and can lower belumosudil concentrations, risking reduced efficacy in chronic graft-versus-host disease. The legacy direction of effect is wrong.
How serious is the interaction between Belumosudil and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase belumosudil to 200 mg twice daily during co-therapy, as per labeling. Monitor clinical response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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