Drug interactions
Belumosudil + Dexlansoprazole
Severity: Moderate
Belumosudil and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belumosudil absorption depends on gastric pH, and proton pump inhibitors lower its exposure. Reduced exposure may lessen control of chronic graft-versus-host disease.
What this interaction means in plain words
Belumosudil and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belumosudil belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces belumosudil solubility and absorption.
What to do
Increase belumosudil to 200 mg twice daily while a PPI is co-administered, and return to the standard dose if the PPI is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Belumosudil
- Amobarbital + Belumosudil Moderate
- Apalutamide + Belumosudil Moderate
- Armodafinil + Belumosudil Moderate
- Belumosudil + Bosentan Moderate
- Belumosudil + Carbamazepine Moderate
- Belumosudil + Efavirenz Moderate
Frequently asked questions
Can I take Belumosudil with Dexlansoprazole?
MediHelp rates the interaction as moderate. Belumosudil and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belumosudil absorption depends on gastric pH, and proton pump inhibitors lower its exposure. Reduced exposure may lessen control of chronic graft-versus-host disease.
How serious is the interaction between Belumosudil and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase belumosudil to 200 mg twice daily while a PPI is co-administered, and return to the standard dose if the PPI is stopped.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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