Drug interactions
Belumosudil + Bosentan
Severity: Moderate
Belumosudil and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower belumosudil concentrations, risking reduced efficacy in chronic graft-versus-host disease.
What this interaction means in plain words
Belumosudil and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belumosudil belongs to Oncology; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing belumosudil metabolism.
What to do
Monitor clinical response and consider increasing belumosudil to the labeled higher dose when used with CYP3A inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Belumosudil
- Amobarbital + Belumosudil Moderate
- Apalutamide + Belumosudil Moderate
- Armodafinil + Belumosudil Moderate
- Belumosudil + Carbamazepine Moderate
- Belumosudil + Dexlansoprazole Moderate
- Belumosudil + Efavirenz Moderate
Frequently asked questions
Can I take Belumosudil with Bosentan?
MediHelp rates the interaction as moderate. Belumosudil and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower belumosudil concentrations, risking reduced efficacy in chronic graft-versus-host disease.
How serious is the interaction between Belumosudil and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing belumosudil to the labeled higher dose when used with CYP3A inducers.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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