Drug interactions
Belumosudil + Lorlatinib
Severity: Moderate
Belumosudil and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belumosudil is metabolized mainly by CYP3A4, which lorlatinib may induce. Reduced belumosudil exposure may impair control of chronic graft-versus-host disease.
What this interaction means in plain words
Belumosudil and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belumosudil belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by lorlatinib increases belumosudil clearance.
What to do
Monitor clinical response of graft-versus-host disease, and consider an alternative to lorlatinib if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Belumosudil
- Amobarbital + Belumosudil Moderate
- Apalutamide + Belumosudil Moderate
- Armodafinil + Belumosudil Moderate
- Belumosudil + Bosentan Moderate
- Belumosudil + Carbamazepine Moderate
- Belumosudil + Dexlansoprazole Moderate
Frequently asked questions
Can I take Belumosudil with Lorlatinib?
MediHelp rates the interaction as moderate. Belumosudil and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belumosudil is metabolized mainly by CYP3A4, which lorlatinib may induce. Reduced belumosudil exposure may impair control of chronic graft-versus-host disease.
How serious is the interaction between Belumosudil and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response of graft-versus-host disease, and consider an alternative to lorlatinib if possible.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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