Drug interactions
Belzutifan + Chloramphenicol
Severity: Moderate
Belzutifan and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP2C19 and raise belzutifan levels, increasing the risk of anemia and hypoxia. Chloramphenicol itself can also cause bone marrow suppression, compounding hematologic risk.
What this interaction means in plain words
Belzutifan and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP2C19-mediated metabolism of belzutifan, plus additive hematologic toxicity.
What to do
Monitor hemoglobin and oxygen saturation closely and reduce the belzutifan dose if anemia or hypoxia develops. Consider an alternative antibiotic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Chloramphenicol?
MediHelp rates the interaction as moderate. Belzutifan and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP2C19 and raise belzutifan levels, increasing the risk of anemia and hypoxia. Chloramphenicol itself can also cause bone marrow suppression, compounding hematologic risk.
How serious is the interaction between Belzutifan and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation closely and reduce the belzutifan dose if anemia or hypoxia develops. Consider an alternative antibiotic where possible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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