Drug interactions
Belzutifan + Dexlansoprazole
Severity: Minor
Belzutifan and Dexlansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Dexlansoprazole is metabolized partly by CYP3A4, so some loss of acid suppression is possible.
What this interaction means in plain words
Belzutifan and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Belzutifan belongs to Miscellaneous; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Belzutifan induces CYP3A4, increasing dexlansoprazole metabolism.
What to do
Monitor for reduced acid control and increase the dexlansoprazole dose if symptoms recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Dexlansoprazole?
MediHelp rates the interaction as minor. Belzutifan and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belzutifan is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Dexlansoprazole is metabolized partly by CYP3A4, so some loss of acid suppression is possible.
How serious is the interaction between Belzutifan and Dexlansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced acid control and increase the dexlansoprazole dose if symptoms recur.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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