Drug interactions
Belzutifan + Flutamide
Severity: Minor
Belzutifan and Flutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower exposure to flutamide and its active hydroxylated metabolite. Antiandrogen effect could be reduced, although the clinical consequence has not been well characterized.
What this interaction means in plain words
Belzutifan and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Belzutifan belongs to Miscellaneous; Flutamide belongs to Endocrine.
Why it happens
Belzutifan induces CYP3A4, increasing the metabolic clearance of flutamide.
What to do
Monitor for loss of antiandrogen effect, such as rising PSA, if the two are combined. Dose increases of flutamide are not routinely recommended, so consider an alternative if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flutamide
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Flutamide?
MediHelp rates the interaction as minor. Belzutifan and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belzutifan induces CYP3A4 and may lower exposure to flutamide and its active hydroxylated metabolite. Antiandrogen effect could be reduced, although the clinical consequence has not been well characterized.
How serious is the interaction between Belzutifan and Flutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antiandrogen effect, such as rising PSA, if the two are combined. Dose increases of flutamide are not routinely recommended, so consider an alternative if efficacy falls.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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