Drug interactions
Belzutifan + Hydrocodone
Severity: Moderate
Belzutifan and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and can lower hydrocodone exposure, potentially reducing analgesia. Stopping belzutifan later may cause hydrocodone levels to rise.
What this interaction means in plain words
Belzutifan and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Hydrocodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 increasing hydrocodone metabolism.
What to do
Monitor pain control and titrate hydrocodone as needed. Reduce the dose and watch for respiratory depression if belzutifan is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Hydrocodone?
MediHelp rates the interaction as moderate. Belzutifan and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and can lower hydrocodone exposure, potentially reducing analgesia. Stopping belzutifan later may cause hydrocodone levels to rise.
How serious is the interaction between Belzutifan and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate hydrocodone as needed. Reduce the dose and watch for respiratory depression if belzutifan is discontinued.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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