Drug interactions
Belzutifan + Imatinib
Severity: Moderate
Belzutifan and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is cleared mainly by UGT2B17 and CYP2C19, and imatinib may inhibit UGT enzymes, which could raise belzutifan exposure and worsen anemia and hypoxia. Belzutifan may also induce CYP3A4 and lower imatinib concentrations, which could reduce its anticancer efficacy.
What this interaction means in plain words
Belzutifan and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Possible UGT2B17 inhibition by imatinib raises belzutifan exposure, while belzutifan induction of CYP3A4 increases imatinib clearance.
What to do
Monitor hemoglobin and oxygen saturation and reduce the belzutifan dose if anemia or hypoxia develops. Watch for loss of imatinib response, such as hematologic or molecular markers, and consider increasing the imatinib dose if it is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Imatinib?
MediHelp rates the interaction as moderate. Belzutifan and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is cleared mainly by UGT2B17 and CYP2C19, and imatinib may inhibit UGT enzymes, which could raise belzutifan exposure and worsen anemia and hypoxia. Belzutifan may also induce CYP3A4 and lower imatinib concentrations, which could reduce its anticancer efficacy.
How serious is the interaction between Belzutifan and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation and reduce the belzutifan dose if anemia or hypoxia develops. Watch for loss of imatinib response, such as hematologic or molecular markers, and consider increasing the imatinib dose if it is needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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