Drug interactions
Belzutifan + Warfarin
Severity: Moderate
Belzutifan and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is a weak CYP3A4 inducer and may lower warfarin exposure modestly, which could reduce anticoagulant effect. The clinical impact is expected to be small but may matter in unstable patients.
What this interaction means in plain words
Belzutifan and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Belzutifan induces CYP3A4, increasing metabolism of R-warfarin.
What to do
Monitor INR more frequently after starting or stopping belzutifan and increase the warfarin dose if INR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Warfarin?
MediHelp rates the interaction as moderate. Belzutifan and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is a weak CYP3A4 inducer and may lower warfarin exposure modestly, which could reduce anticoagulant effect. The clinical impact is expected to be small but may matter in unstable patients.
How serious is the interaction between Belzutifan and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently after starting or stopping belzutifan and increase the warfarin dose if INR falls.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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