Drug interactions
Bemiparin + Mefenamic acid
Severity: Major
Bemiparin and Mefenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bemiparin is a low-molecular-weight heparin and NSAIDs impair platelet function and irritate the gastric mucosa. Combined use raises the risk of clinically significant bleeding, including gastrointestinal hemorrhage.
What this interaction means in plain words
Bemiparin and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect of heparin-mediated anti-Xa activity and NSAID-induced platelet inhibition and mucosal injury.
What to do
Avoid the combination where possible and use paracetamol instead; if unavoidable, monitor for bleeding and hemoglobin and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Bemiparin with Mefenamic acid?
MediHelp rates the interaction as major. Bemiparin and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bemiparin is a low-molecular-weight heparin and NSAIDs impair platelet function and irritate the gastric mucosa. Combined use raises the risk of clinically significant bleeding, including gastrointestinal hemorrhage.
How serious is the interaction between Bemiparin and Mefenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol instead; if unavoidable, monitor for bleeding and hemoglobin and consider gastroprotection.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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