Drug interactions
Bempedoic acid + Simvastatin
Severity: Moderate
Bempedoic acid and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bempedoic acid raises simvastatin exposure, which increases the risk of statin-related myopathy and rhabdomyolysis. The labeling limits the simvastatin dose when the two are combined.
What this interaction means in plain words
Bempedoic acid and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bempedoic acid belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Bempedoic acid is thought to inhibit OATP1B1/1B3 hepatic uptake of simvastatin and its acid, raising systemic concentrations.
What to do
Do not exceed simvastatin 20 mg daily with bempedoic acid. Counsel the patient to report unexplained muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Bempedoic acid
- Bempedoic acid + Pravastatin Moderate
Frequently asked questions
Can I take Bempedoic acid with Simvastatin?
MediHelp rates the interaction as moderate. Bempedoic acid and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bempedoic acid raises simvastatin exposure, which increases the risk of statin-related myopathy and rhabdomyolysis. The labeling limits the simvastatin dose when the two are combined.
How serious is the interaction between Bempedoic acid and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed simvastatin 20 mg daily with bempedoic acid. Counsel the patient to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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