Drug interactions
Bempedoic acid + Pravastatin
Severity: Moderate
Bempedoic acid and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bempedoic acid increases pravastatin exposure, which may raise the risk of myopathy. Labeling advises limiting the pravastatin dose.
What this interaction means in plain words
Bempedoic acid and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bempedoic acid belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Bempedoic acid likely inhibits OATP1B1/1B3 hepatic uptake of pravastatin.
What to do
Do not exceed pravastatin 40 mg daily with bempedoic acid. Monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Bempedoic acid
- Bempedoic acid + Simvastatin Moderate
Frequently asked questions
Can I take Bempedoic acid with Pravastatin?
MediHelp rates the interaction as moderate. Bempedoic acid and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bempedoic acid increases pravastatin exposure, which may raise the risk of myopathy. Labeling advises limiting the pravastatin dose.
How serious is the interaction between Bempedoic acid and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed pravastatin 40 mg daily with bempedoic acid. Monitor for muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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