Drug interactions
Benazepril + Canagliflozin-metformin
Severity: Moderate
Benazepril and Canagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benazepril can increase potassium, and combined use with canagliflozin may add to this, particularly with renal impairment. ACE inhibitors may also enhance glucose-lowering effects, and renal decline can raise metformin accumulation risk.
What this interaction means in plain words
Benazepril and Canagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Canagliflozin-metformin belongs to Endocrine.
Why it happens
ACE inhibition lowers aldosterone and may improve insulin sensitivity, while renal effects can reduce metformin clearance.
What to do
Monitor potassium, renal function and blood glucose, and watch for volume depletion. Reassess metformin dosing if eGFR declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Canagliflozin-metformin?
MediHelp rates the interaction as moderate. Benazepril and Canagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benazepril can increase potassium, and combined use with canagliflozin may add to this, particularly with renal impairment. ACE inhibitors may also enhance glucose-lowering effects, and renal decline can raise metformin accumulation risk.
How serious is the interaction between Benazepril and Canagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, renal function and blood glucose, and watch for volume depletion. Reassess metformin dosing if eGFR declines.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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