Drug interactions
Benazepril + Carbidopa-levodopa
Severity: Moderate
Benazepril and Carbidopa-levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and benazepril lowers blood pressure through ACE inhibition. Combined use may cause additive hypotension, particularly at initiation or after dose increases.
What this interaction means in plain words
Benazepril and Carbidopa-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Carbidopa-levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of levodopa-related vasodilation and autonomic effects with ACE inhibition.
What to do
Monitor sitting and standing blood pressure when starting levodopa, and reduce the benazepril dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Carbidopa-levodopa?
MediHelp rates the interaction as moderate. Benazepril and Carbidopa-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and benazepril lowers blood pressure through ACE inhibition. Combined use may cause additive hypotension, particularly at initiation or after dose increases.
How serious is the interaction between Benazepril and Carbidopa-levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when starting levodopa, and reduce the benazepril dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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