Drug interactions
Benazepril + Chlorpropamide
Severity: Moderate
Benazepril and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can potentiate the glucose-lowering effect of sulfonylureas, and chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
What this interaction means in plain words
Benazepril and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity, adding to sulfonylurea-stimulated insulin secretion.
What to do
Monitor blood glucose after starting or changing benazepril and reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Benazepril with Chlorpropamide?
MediHelp rates the interaction as moderate. Benazepril and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can potentiate the glucose-lowering effect of sulfonylureas, and chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Benazepril and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing benazepril and reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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