Drug interactions
Benazepril + Chlorthalidone
Severity: Moderate
Benazepril and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination provides additive blood pressure lowering and can cause first-dose or volume-related hypotension. In patients who are volume-depleted or have renal artery stenosis, it may also cause acute decline in renal function.
What this interaction means in plain words
Benazepril and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion activates the renin-angiotensin system, so ACE inhibition produces exaggerated hypotension and reduced glomerular filtration pressure.
What to do
Monitor blood pressure, serum creatinine and potassium after initiation and dose changes. Consider lowering or temporarily holding the diuretic when starting the ACE inhibitor in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Chlorthalidone?
MediHelp rates the interaction as moderate. Benazepril and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination provides additive blood pressure lowering and can cause first-dose or volume-related hypotension. In patients who are volume-depleted or have renal artery stenosis, it may also cause acute decline in renal function.
How serious is the interaction between Benazepril and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after initiation and dose changes. Consider lowering or temporarily holding the diuretic when starting the ACE inhibitor in volume-depleted patients.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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