Drug interactions
Benazepril + Clozapine
Severity: Moderate
Benazepril and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine frequently causes orthostatic hypotension, especially during titration, and an ACE inhibitor may worsen this effect, raising the risk of syncope and falls.
What this interaction means in plain words
Benazepril and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Clozapine belongs to Central Nervous System.
Why it happens
Additive hypotension from clozapine alpha-1 adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and heart rate during clozapine titration and reduce or hold benazepril if orthostatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Benazepril with Clozapine?
MediHelp rates the interaction as moderate. Benazepril and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine frequently causes orthostatic hypotension, especially during titration, and an ACE inhibitor may worsen this effect, raising the risk of syncope and falls.
How serious is the interaction between Benazepril and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during clozapine titration and reduce or hold benazepril if orthostatic hypotension develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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