Drug interactions
Benazepril + Cyclosporin
Severity: Moderate
Benazepril and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both cyclosporine and ACE inhibitors affect renal hemodynamics, and together they can reduce glomerular filtration and cause acute kidney injury. Both can also raise potassium, so hyperkalemia is a risk.
What this interaction means in plain words
Benazepril and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Cyclosporin belongs to Miscellaneous.
Why it happens
Additive hemodynamic renal effects (afferent vasoconstriction with cyclosporine and efferent dilation with ACE inhibition) and additive hyperkalemia.
What to do
Monitor serum creatinine and potassium after starting or adjusting benazepril and during intercurrent illness. Reduce doses or stop if renal function declines or hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Cyclosporin?
MediHelp rates the interaction as moderate. Benazepril and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both cyclosporine and ACE inhibitors affect renal hemodynamics, and together they can reduce glomerular filtration and cause acute kidney injury. Both can also raise potassium, so hyperkalemia is a risk.
How serious is the interaction between Benazepril and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and potassium after starting or adjusting benazepril and during intercurrent illness. Reduce doses or stop if renal function declines or hyperkalemia develops.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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