Drug interactions
Benazepril + Drospirenone
Severity: Moderate
Benazepril and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is a spironolactone-like progestin with antimineralocorticoid activity that can raise serum potassium. Combined with an ACE inhibitor, which also reduces potassium excretion, hyperkalemia can develop, particularly in patients with renal impairment or diabetes.
What this interaction means in plain words
Benazepril and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention through ACE inhibitor-mediated aldosterone suppression and drospirenone's antimineralocorticoid effect.
What to do
Check serum potassium and renal function during the first cycle of combined use and periodically afterward. Consider a different contraceptive in patients with renal impairment or other hyperkalemia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Benazepril with Drospirenone?
MediHelp rates the interaction as moderate. Benazepril and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone is a spironolactone-like progestin with antimineralocorticoid activity that can raise serum potassium. Combined with an ACE inhibitor, which also reduces potassium excretion, hyperkalemia can develop, particularly in patients with renal impairment or diabetes.
How serious is the interaction between Benazepril and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function during the first cycle of combined use and periodically afterward. Consider a different contraceptive in patients with renal impairment or other hyperkalemia risk factors.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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