Drug interactions
Benazepril + Empagliflozin-metformin
Severity: Moderate
Benazepril and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function, which raises the risk of metformin accumulation and lactic acidosis, and combined with empagliflozin may increase volume depletion and acute kidney injury risk.
What this interaction means in plain words
Benazepril and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
ACE inhibition can improve insulin sensitivity and alter renal hemodynamics, and reduced renal function decreases metformin clearance.
What to do
Monitor renal function, volume status and blood glucose after starting or adjusting benazepril. Stop metformin if eGFR falls below labeled limits or acute kidney injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Benazepril and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function, which raises the risk of metformin accumulation and lactic acidosis, and combined with empagliflozin may increase volume depletion and acute kidney injury risk.
How serious is the interaction between Benazepril and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, volume status and blood glucose after starting or adjusting benazepril. Stop metformin if eGFR falls below labeled limits or acute kidney injury develops.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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