Drug interactions
Benazepril + Enoxaparin
Severity: Moderate
Benazepril and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can suppress aldosterone secretion, and ACE inhibitors also lower aldosterone activity. Together they may increase the risk of hyperkalemia, especially in patients with renal impairment or diabetes or with prolonged heparin therapy.
What this interaction means in plain words
Benazepril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone-mediated potassium excretion.
What to do
Monitor serum potassium, particularly in patients with renal impairment, diabetes or therapy lasting more than several days. Treat hyperkalemia if it occurs and reassess the need for each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Benazepril with Enoxaparin?
MediHelp rates the interaction as moderate. Benazepril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can suppress aldosterone secretion, and ACE inhibitors also lower aldosterone activity. Together they may increase the risk of hyperkalemia, especially in patients with renal impairment or diabetes or with prolonged heparin therapy.
How serious is the interaction between Benazepril and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly in patients with renal impairment, diabetes or therapy lasting more than several days. Treat hyperkalemia if it occurs and reassess the need for each drug.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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