Drug interactions
Benazepril + Epoprostenol
Severity: Moderate
Benazepril and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator and can add to the blood pressure lowering effect of benazepril. This may cause symptomatic hypotension, particularly during dose titration.
What this interaction means in plain words
Benazepril and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive vasodilation through prostacyclin receptor activation and angiotensin-converting enzyme inhibition.
What to do
Monitor blood pressure and symptoms of hypotension when initiating or changing doses. Reduce the benazepril dose if hypotension limits epoprostenol titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Benazepril with Epoprostenol?
MediHelp rates the interaction as moderate. Benazepril and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator and can add to the blood pressure lowering effect of benazepril. This may cause symptomatic hypotension, particularly during dose titration.
How serious is the interaction between Benazepril and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when initiating or changing doses. Reduce the benazepril dose if hypotension limits epoprostenol titration.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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