Drug interactions
Benazepril + Gliclazide
Severity: Minor
Benazepril and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may improve insulin sensitivity and in some patients enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. The risk is modest and mostly occurs when therapy is started.
What this interaction means in plain words
Benazepril and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity through raised bradykinin levels, adding to sulfonylurea action.
What to do
Monitor blood glucose when benazepril is started, especially in the elderly or those with renal impairment. Lower the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Gliclazide?
MediHelp rates the interaction as minor. Benazepril and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may improve insulin sensitivity and in some patients enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. The risk is modest and mostly occurs when therapy is started.
How serious is the interaction between Benazepril and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when benazepril is started, especially in the elderly or those with renal impairment. Lower the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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