Drug interactions
Benazepril + Glipizide-metformin
Severity: Moderate
Benazepril and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the hypoglycemic effect of sulfonylureas and metformin. Hypoglycemia is mainly seen in the early period of combination therapy.
What this interaction means in plain words
Benazepril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, producing additive glucose lowering.
What to do
Monitor blood glucose when starting benazepril and reduce the glipizide dose if hypoglycemia occurs. Monitor renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Glipizide-metformin?
MediHelp rates the interaction as moderate. Benazepril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may enhance the hypoglycemic effect of sulfonylureas and metformin. Hypoglycemia is mainly seen in the early period of combination therapy.
How serious is the interaction between Benazepril and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting benazepril and reduce the glipizide dose if hypoglycemia occurs. Monitor renal function.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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