Drug interactions
Benazepril + Glyburide-metformin
Severity: Moderate
Benazepril and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas and metformin, occasionally leading to hypoglycemia. Reduced renal function with ACE inhibitors may also raise metformin exposure.
What this interaction means in plain words
Benazepril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Improved insulin sensitivity via bradykinin-related effects adds to antidiabetic activity; renal effects may alter metformin clearance.
What to do
Monitor blood glucose, particularly early in therapy, and reduce the glyburide dose if hypoglycemia occurs. Monitor renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Glyburide-metformin?
MediHelp rates the interaction as moderate. Benazepril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas and metformin, occasionally leading to hypoglycemia. Reduced renal function with ACE inhibitors may also raise metformin exposure.
How serious is the interaction between Benazepril and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, particularly early in therapy, and reduce the glyburide dose if hypoglycemia occurs. Monitor renal function periodically.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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