Drug interactions
Benazepril + Imipramine
Severity: Minor
Benazepril and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can cause orthostatic hypotension through alpha-blockade, and this may add to the blood pressure lowering of benazepril. Dizziness and falls are the main concerns, especially in older adults.
What this interaction means in plain words
Benazepril and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects: tricyclic alpha-adrenergic blockade combined with ACE inhibition.
What to do
Monitor sitting and standing blood pressure when starting or adjusting either drug, and lower the dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Benazepril with Imipramine?
MediHelp rates the interaction as minor. Benazepril and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imipramine can cause orthostatic hypotension through alpha-blockade, and this may add to the blood pressure lowering of benazepril. Dizziness and falls are the main concerns, especially in older adults.
How serious is the interaction between Benazepril and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when starting or adjusting either drug, and lower the dose if symptomatic hypotension develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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