Drug interactions
Benazepril + Insulin degludec-liraglutide
Severity: Moderate
Benazepril and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The effect is most apparent in the first weeks of ACE inhibitor therapy.
What this interaction means in plain words
Benazepril and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, adding to the glucose-lowering effect of insulin and liraglutide.
What to do
Monitor blood glucose more closely when benazepril is started or the dose is increased, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Benazepril and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The effect is most apparent in the first weeks of ACE inhibitor therapy.
How serious is the interaction between Benazepril and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when benazepril is started or the dose is increased, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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