Drug interactions
Benazepril + Insulin degludec
Severity: Moderate
Benazepril and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and thereby enhance the glucose-lowering effect of insulin. Episodes of hypoglycemia may occur, especially after starting the ACE inhibitor.
What this interaction means in plain words
Benazepril and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Improved insulin sensitivity with ACE inhibition adds to exogenous insulin action.
What to do
Monitor blood glucose closely when benazepril is started or the dose changed. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Benazepril with Insulin degludec?
MediHelp rates the interaction as moderate. Benazepril and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and thereby enhance the glucose-lowering effect of insulin. Episodes of hypoglycemia may occur, especially after starting the ACE inhibitor.
How serious is the interaction between Benazepril and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when benazepril is started or the dose changed. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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