Drug interactions
Benazepril + Insulin glargine-lixisenatide
Severity: Minor
Benazepril and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of insulin, with hypoglycemia reported especially in the early weeks of therapy. The effect is generally small.
What this interaction means in plain words
Benazepril and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Increased insulin sensitivity, possibly via bradykinin-mediated enhancement of glucose uptake.
What to do
Monitor blood glucose when starting benazepril and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Benazepril and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of insulin, with hypoglycemia reported especially in the early weeks of therapy. The effect is generally small.
How serious is the interaction between Benazepril and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting benazepril and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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