Drug interactions
Benazepril + Isoflurane
Severity: Moderate
Benazepril and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as isoflurane cause vasodilation and myocardial depression, and patients on ACE inhibitors may develop marked hypotension during anesthesia. The hypotension can be refractory to usual vasopressors.
What this interaction means in plain words
Benazepril and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Isoflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation with blunting of angiotensin II-dependent blood pressure compensation.
What to do
Anesthesia staff should be aware of ACE inhibitor use and monitor blood pressure closely. Consider withholding benazepril on the morning of surgery per local protocol and treat hypotension with fluids and vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Benazepril with Isoflurane?
MediHelp rates the interaction as moderate. Benazepril and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as isoflurane cause vasodilation and myocardial depression, and patients on ACE inhibitors may develop marked hypotension during anesthesia. The hypotension can be refractory to usual vasopressors.
How serious is the interaction between Benazepril and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anesthesia staff should be aware of ACE inhibitor use and monitor blood pressure closely. Consider withholding benazepril on the morning of surgery per local protocol and treat hypotension with fluids and vasopressors.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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