Drug interactions
Benazepril + Isosorbide dinitrate
Severity: Moderate
Benazepril and Isosorbide dinitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates cause venous and arterial dilation, and combining them with an ACE inhibitor can lower blood pressure further. This is often used intentionally but may cause symptomatic hypotension, especially at initiation.
What this interaction means in plain words
Benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Benazepril with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates cause venous and arterial dilation, and combining them with an ACE inhibitor can lower blood pressure further. This is often used intentionally but may cause symptomatic hypotension, especially at initiation.
How serious is the interaction between Benazepril and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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