Drug interactions
Benazepril + Lofexidine
Severity: Moderate
Benazepril and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and an ACE inhibitor adds to the hypotensive effect. Patients may develop symptomatic hypotension, dizziness or syncope, particularly at the start of treatment.
What this interaction means in plain words
Benazepril and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from central alpha-2 agonism and reduced angiotensin II formation.
What to do
Monitor blood pressure and heart rate during lofexidine treatment and consider reducing or holding the antihypertensive if hypotension or bradycardia develops. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Benazepril with Lofexidine?
MediHelp rates the interaction as moderate. Benazepril and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and an ACE inhibitor adds to the hypotensive effect. Patients may develop symptomatic hypotension, dizziness or syncope, particularly at the start of treatment.
How serious is the interaction between Benazepril and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during lofexidine treatment and consider reducing or holding the antihypertensive if hypotension or bradycardia develops. Advise patients to rise slowly.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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