Drug interactions
Benazepril + Metformin-pioglitazone
Severity: Moderate
Benazepril and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in susceptible patients, which could raise metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Benazepril and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity and, via hemodynamic effects on the kidney, reduce metformin clearance in some patients.
What to do
Monitor blood glucose and renal function, particularly after initiation or dose changes, and adjust the metformin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Benazepril and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in susceptible patients, which could raise metformin accumulation and lactic acidosis risk.
How serious is the interaction between Benazepril and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, particularly after initiation or dose changes, and adjust the metformin dose if renal function declines.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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