Drug interactions
Benazepril + Metformin-repaglinide
Severity: Moderate
Benazepril and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and the risk of hypoglycemia with antidiabetic drugs. They may also worsen renal function, which raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Benazepril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
ACE inhibition enhances insulin sensitivity, and renal hemodynamic effects may reduce metformin clearance.
What to do
Monitor glucose and renal function, especially when starting benazepril or changing the dose, and reduce repaglinide if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Benazepril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and the risk of hypoglycemia with antidiabetic drugs. They may also worsen renal function, which raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Benazepril and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function, especially when starting benazepril or changing the dose, and reduce repaglinide if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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