Drug interactions
Benazepril + Phenelzine
Severity: Moderate
Benazepril and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine, a monoamine oxidase inhibitor, commonly causes orthostatic hypotension. Combined with benazepril this can become more pronounced and lead to dizziness, syncope, or falls.
What this interaction means in plain words
Benazepril and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Why it happens
Additive hypotension from MAO inhibitor-related autonomic effects and ACE inhibition.
What to do
Monitor supine and standing blood pressure when starting or adjusting either drug. Reduce the antihypertensive dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Benazepril with Phenelzine?
MediHelp rates the interaction as moderate. Benazepril and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenelzine, a monoamine oxidase inhibitor, commonly causes orthostatic hypotension. Combined with benazepril this can become more pronounced and lead to dizziness, syncope, or falls.
How serious is the interaction between Benazepril and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or adjusting either drug. Reduce the antihypertensive dose if orthostatic symptoms occur.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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