Drug interactions
Benazepril + Rasagiline
Severity: Moderate
Benazepril and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline can cause orthostatic hypotension, and combining it with benazepril may increase blood pressure lowering. Patients with Parkinson disease may already have autonomic dysfunction, raising fall risk.
What this interaction means in plain words
Benazepril and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from MAO-B inhibition-related orthostasis and ACE inhibition.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the antihypertensive dose if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Benazepril with Rasagiline?
MediHelp rates the interaction as moderate. Benazepril and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline can cause orthostatic hypotension, and combining it with benazepril may increase blood pressure lowering. Patients with Parkinson disease may already have autonomic dysfunction, raising fall risk.
How serious is the interaction between Benazepril and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the antihypertensive dose if orthostatic symptoms develop.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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