Drug interactions
Benazepril + Spironolactone
Severity: Major
Benazepril and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce potassium excretion, so together they can cause clinically significant hyperkalemia, particularly in renal impairment, diabetes or older age. Severe hyperkalemia can cause dangerous arrhythmias.
What this interaction means in plain words
Benazepril and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone production while spironolactone blocks the mineralocorticoid receptor, additively reducing renal potassium excretion.
What to do
Check potassium and creatinine at baseline, within about one week, and regularly thereafter. Avoid potassium supplements and salt substitutes, and reduce or stop spironolactone if potassium rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Spironolactone?
MediHelp rates the interaction as major. Benazepril and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce potassium excretion, so together they can cause clinically significant hyperkalemia, particularly in renal impairment, diabetes or older age. Severe hyperkalemia can cause dangerous arrhythmias.
How serious is the interaction between Benazepril and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine at baseline, within about one week, and regularly thereafter. Avoid potassium supplements and salt substitutes, and reduce or stop spironolactone if potassium rises significantly.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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