Drug interactions
Benazepril + Tretinoin
Severity: Minor
Benazepril and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic tretinoin has been associated with hypotension in some patients, and this may theoretically add to the effect of benazepril. The evidence for a clinically important interaction is limited.
What this interaction means in plain words
Benazepril and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Possible additive hypotensive effect; mechanism not well established.
What to do
Monitor blood pressure when oral tretinoin is used with the ACE inhibitor and adjust the antihypertensive dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Benazepril with Tretinoin?
MediHelp rates the interaction as minor. Benazepril and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic tretinoin has been associated with hypotension in some patients, and this may theoretically add to the effect of benazepril. The evidence for a clinically important interaction is limited.
How serious is the interaction between Benazepril and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when oral tretinoin is used with the ACE inhibitor and adjust the antihypertensive dose if needed.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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