Drug interactions
Benazepril + Triamterene
Severity: Major
Benazepril and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene blocks renal sodium channels and reduces potassium excretion, while benazepril lowers aldosterone. Together they can cause serious hyperkalemia, especially in renal impairment, diabetes or older patients.
What this interaction means in plain words
Benazepril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Additive potassium retention from ENaC blockade and ACE inhibition-related aldosterone reduction.
What to do
Monitor potassium and renal function at baseline, within the first week, and periodically. Avoid potassium supplements and salt substitutes, and stop triamterene if hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Triamterene?
MediHelp rates the interaction as major. Benazepril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triamterene blocks renal sodium channels and reduces potassium excretion, while benazepril lowers aldosterone. Together they can cause serious hyperkalemia, especially in renal impairment, diabetes or older patients.
How serious is the interaction between Benazepril and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and renal function at baseline, within the first week, and periodically. Avoid potassium supplements and salt substitutes, and stop triamterene if hyperkalemia occurs.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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