Drug interactions
Bendamustine + Carbamazepine
Severity: Moderate
Bendamustine and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendamustine is partly metabolized by CYP1A2 to active metabolites, and the effect of an inducer on efficacy and toxicity is unclear. Carbamazepine has weak CYP1A2 induction.
What this interaction means in plain words
Bendamustine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bendamustine belongs to Oncology; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine may induce CYP1A2, altering formation of bendamustine metabolites.
What to do
Monitor response and toxicity such as myelosuppression. Consider a non-inducing antiseizure drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Bendamustine
Frequently asked questions
Can I take Bendamustine with Carbamazepine?
MediHelp rates the interaction as moderate. Bendamustine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bendamustine is partly metabolized by CYP1A2 to active metabolites, and the effect of an inducer on efficacy and toxicity is unclear. Carbamazepine has weak CYP1A2 induction.
How serious is the interaction between Bendamustine and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and toxicity such as myelosuppression. Consider a non-inducing antiseizure drug.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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