Drug interactions
Bendamustine + Cisplatin
Severity: Moderate
Bendamustine and Cisplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, and cisplatin also causes renal toxicity that may alter drug handling and tolerance. Combined therapy increases the likelihood of significant cytopenias.
What this interaction means in plain words
Bendamustine and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bendamustine belongs to Oncology; Cisplatin belongs to Oncology.
Why it happens
Additive myelosuppression from DNA-damaging effects.
What to do
Monitor blood counts and renal function, and adjust doses or delay cycles for severe toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bendamustine
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Bendamustine with Cisplatin?
MediHelp rates the interaction as moderate. Bendamustine and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, and cisplatin also causes renal toxicity that may alter drug handling and tolerance. Combined therapy increases the likelihood of significant cytopenias.
How serious is the interaction between Bendamustine and Cisplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function, and adjust doses or delay cycles for severe toxicity.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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