Drug interactions
Bendamustine + Ethinyl estradiol-drospirenone
Severity: Minor
Bendamustine and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendamustine is partly cleared via CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor. Exposure to bendamustine could rise slightly, but the active metabolites are minor and clinical impact is probably small.
What this interaction means in plain words
Bendamustine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol may reduce bendamustine metabolism.
What to do
No dose adjustment is needed; monitor for bendamustine myelosuppression per routine practice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendamustine and Ethinyl estradiol-drospirenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Bendamustine
Frequently asked questions
Can I take Bendamustine with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Bendamustine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bendamustine is partly cleared via CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor. Exposure to bendamustine could rise slightly, but the active metabolites are minor and clinical impact is probably small.
How serious is the interaction between Bendamustine and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for bendamustine myelosuppression per routine practice.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
