Drug interactions
Bendamustine + Lasmiditan
Severity: Minor
Bendamustine and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and in the gut, which could raise exposure to P-gp substrates. Bendamustine is not a clearly important P-gp substrate and is mainly cleared by hydrolysis, so a meaningful interaction is unlikely.
What this interaction means in plain words
Bendamustine and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Possible P-gp inhibition by lasmiditan; clinical relevance for bendamustine is unestablished.
What to do
No specific action is needed beyond routine monitoring of bendamustine toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bendamustine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Bendamustine with Lasmiditan?
MediHelp rates the interaction as minor. Bendamustine and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro and in the gut, which could raise exposure to P-gp substrates. Bendamustine is not a clearly important P-gp substrate and is mainly cleared by hydrolysis, so a meaningful interaction is unlikely.
How serious is the interaction between Bendamustine and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of bendamustine toxicity.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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