Drug interactions
Bendroflumethiazide + Ethinyl estradiol-drospirenone
Severity: Minor
Bendroflumethiazide and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone tends to raise serum potassium while thiazides such as bendroflumethiazide lower it through renal losses. The opposing effects may partly offset each other, so the net change is generally small.
What this interaction means in plain words
Bendroflumethiazide and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing potassium effects: aldosterone antagonism by drospirenone versus increased distal potassium excretion from thiazide diuresis.
What to do
No dose change is usually needed. Check serum potassium and renal function in the first cycle and periodically thereafter.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Bendroflumethiazide with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Bendroflumethiazide and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone tends to raise serum potassium while thiazides such as bendroflumethiazide lower it through renal losses. The opposing effects may partly offset each other, so the net change is generally small.
How serious is the interaction between Bendroflumethiazide and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Check serum potassium and renal function in the first cycle and periodically thereafter.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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