Drug interactions
Bendroflumethiazide + Furosemide
Severity: Moderate
Bendroflumethiazide and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sequential nephron blockade produces a strong diuretic effect, which can cause marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment. The combination is sometimes used deliberately for resistant edema.
What this interaction means in plain words
Bendroflumethiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive natriuresis and kaliuresis from blocking sodium reabsorption at the loop of Henle and distal tubule.
What to do
Monitor electrolytes, renal function and weight within days of starting, and supplement potassium or add a potassium-sparing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Bendroflumethiazide with Furosemide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sequential nephron blockade produces a strong diuretic effect, which can cause marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment. The combination is sometimes used deliberately for resistant edema.
How serious is the interaction between Bendroflumethiazide and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function and weight within days of starting, and supplement potassium or add a potassium-sparing agent if needed.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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