Drug interactions
Bendroflumethiazide + Losartan
Severity: Moderate
Bendroflumethiazide and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics are frequently combined with losartan, giving additive blood pressure lowering. The ARB offsets thiazide-induced potassium loss, but volume depletion may cause hypotension or reduced renal function.
What this interaction means in plain words
Bendroflumethiazide and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects from diuresis and angiotensin receptor blockade, with opposing effects on potassium.
What to do
Monitor blood pressure, renal function and electrolytes after starting or adjusting doses. Watch for hypotension in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Losartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics are frequently combined with losartan, giving additive blood pressure lowering. The ARB offsets thiazide-induced potassium loss, but volume depletion may cause hypotension or reduced renal function.
How serious is the interaction between Bendroflumethiazide and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or adjusting doses. Watch for hypotension in volume-depleted patients.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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