Drug interactions
Bendroflumethiazide + Saxagliptin
Severity: Minor
Bendroflumethiazide and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, especially at higher doses, which may partly counteract saxagliptin. The effect is usually modest.
What this interaction means in plain words
Bendroflumethiazide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: thiazides impair insulin secretion and sensitivity, partly via potassium depletion.
What to do
Monitor glycemic control when a thiazide is started or its dose increased. Adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Bendroflumethiazide with Saxagliptin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, especially at higher doses, which may partly counteract saxagliptin. The effect is usually modest.
How serious is the interaction between Bendroflumethiazide and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when a thiazide is started or its dose increased. Adjust antidiabetic therapy if needed.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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