Drug interactions
Bendroflumethiazide + Tizanidine
Severity: Minor
Bendroflumethiazide and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine lowers blood pressure and a thiazide diuretic does so through volume and vascular effects. Together they may cause additive hypotension and orthostatic dizziness.
What this interaction means in plain words
Bendroflumethiazide and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism and diuretic-induced volume depletion.
What to do
Monitor blood pressure and counsel the patient to rise slowly. Adjust the dose of either agent if orthostatic symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Bendroflumethiazide with Tizanidine?
MediHelp rates the interaction as minor. Bendroflumethiazide and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tizanidine lowers blood pressure and a thiazide diuretic does so through volume and vascular effects. Together they may cause additive hypotension and orthostatic dizziness.
How serious is the interaction between Bendroflumethiazide and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel the patient to rise slowly. Adjust the dose of either agent if orthostatic symptoms appear.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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