Drug interactions
Benperidol + Clomipramine
Severity: Moderate
Benperidol and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and benperidol is a butyrophenone antipsychotic that may also affect cardiac conduction. Together they can increase drowsiness and impair psychomotor performance, with possible additive QT effects.
What this interaction means in plain words
Benperidol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible additive effects on cardiac repolarization.
What to do
Monitor for sedation and orthostatic hypotension and consider an ECG in patients with cardiac risk factors. Adjust doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Benperidol with Clomipramine?
MediHelp rates the interaction as moderate. Benperidol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and benperidol is a butyrophenone antipsychotic that may also affect cardiac conduction. Together they can increase drowsiness and impair psychomotor performance, with possible additive QT effects.
How serious is the interaction between Benperidol and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension and consider an ECG in patients with cardiac risk factors. Adjust doses if impairment occurs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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